What does melanoma cancer live on?
I was confused? One report says glucose, the other
says NOT glucose but the amino acid glutamine is what melanoma lives on.
These
are the two articles that seemed like a conflict to me:
I
decided to ask the expert and see if he will answer me?
He
kindly responded first thing! So I
thought I would post his answer for others to read. Thank you Jeff!
The
statement in the article that confused me was " Unlike normal cells,
melanoma and other cancer cells rely on the amino acid glutamine instead of
glucose for the energy" Which in my mind implied that melanoma does not
use glucose at all!
I
emailed the scientist named in the article on glutamine and below is his
answer:
There
are many different ways to "starve" a cancer - and it seems that
either glucose or glutamine can do the trick. The picture is a very simple
version I found showing that glucose and glutamine have many common pathways
through energy generation in the TCA cycle and breakdown into lipids, amino
acids and nucleotides. Therefore blocking either will have similar effects on
the cancer cell.
However,
it is a very complex balance, and certainly our work has only been done in the
lab, not in any animal models or humans, so we still have a way to go to fully
understand whether we can target these pathways. Interestingly we have also
shown that blocking another amino acid, leucine, can slow prostate cancer cells
- again adding to the complexity, but showing that there are a number of
nutrient that are critical for cancer cells.
The
key word in the statement is energy - glucose is used more for the generation
of other molecules in cancer rather than in normal cells where energy
generation is key, and instead glutamine is pulled in and used for energy
generation in cancer cells. So they are both critical for the cells, but it is
just a switch in their "normal" roles. But under certain conditions
and in different tumours, this can be different, and we are still a way off
finding out what mediates these differences (although as you can see, glucose
is important in the BRAF mutant tumours according to the other study). We saw
no difference for glutamine in either BRAF mutant or normal BRAF tumours in our
study though.
Cheers,
Jeff
JEFF
HOLST, PhD
Head,
Origins of Cancer Laboratory
Centenary
Institute
Thanks
so much Jeff! You are awesome!!!!
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